Welcome to Theoretical Systems Biology Group

We are interested in interdisciplinary research related to biologically relevant problems and comprehending

them from a theoretical as well as experimental point of view.  We work coherently with experimentalists (or

perform experiments in our lab) to develop integrative mathematical models to understand the phenomenon

such as cell cycle, signalling pathways, stem cell self renewal and differentiation etc. using different facets

of mathematical and computational modelling approaches. In our research, we use techniques related to 

nonlinear dynamics, bifurcation analysis, stochastic methods, chemical kinetics, parameter estimation and

many other such important methods to uncover the underlying principles in biological processes.

Our Latest Works

Deciphering the dynamical origin of mixed population during neural stem cell development

D. Sengupta and S. Kar, Biophysical Journal, 114, 992-1004, (2018).

Alteration in microRNA-17-92 dynamics accounts for differential nature of cellular proliferation


D. Sengupta*, G. Vinodhini* and S. Kar, FEBS Letters, 592, 446-458, (2018).

(* Equal contribution 1st author)

Alteration in microRNA expression governs the nature and timing of cellular fate commitment

    D. Sengupta and S. Kar, ACS Chemical Neuroscience, 9(4), 725-732, (2018).

Decoding the regulatory mechanism of Glucose and Insulin induced Phosphatidyinositol 3,4,5-Trisphosphate dynamics in β-cells

T. Samanta*, P. Sharma*, D. Kukri and S. Kar,

Molecular BioSystems, 13, 1512, (2017).

(* Equal contribution 1st author)


Dr. Sandip Kar
Department of Chemistry
Indian Institute of Technology, Bombay


Office:                                           Lab:

Tel 91 22 2576 7193                      Tel 91 22 2576 4192

mobile: 91 9619747193



The Science & 

Mathematics University

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